Medicinal Mushrooms for Long Term Brain Injuries

Brain injuries can have profound and lasting effects on an individual’s cognitive and neurological health. The search for effective treatments to aid in the recovery and management of long-term brain injuries has led researchers to explore various natural remedies, including medicinal mushrooms. Medicinal mushrooms have been used for centuries in traditional medicine, and recent scientific studies suggest they may offer significant benefits for brain health and recovery from injuries. This blog post delves into the potential of medicinal mushrooms in supporting recovery from long-term brain injuries, backed by scientific evidence.

Understanding Long-Term Brain Injuries

Long-term brain injuries, such as traumatic brain injuries (TBI), stroke, and chronic traumatic encephalopathy (CTE), can result in a wide range of cognitive, emotional, and physical impairments. These injuries often lead to chronic issues such as memory loss, difficulty concentrating, mood swings, and even neurodegenerative conditions like Alzheimer's and Parkinson's diseases.

The brain’s ability to heal and regenerate after such injuries is limited, making it crucial to find therapeutic interventions that can support neuroprotection, neurogenesis (the growth of new neurons), and overall brain function.

The Promise of Medicinal Mushrooms

Medicinal mushrooms have garnered attention for their neuroprotective properties and potential to enhance brain health. Key mushrooms that have shown promise in this area include Lion’s Mane (Hericium erinaceus), Reishi (Ganoderma lucidum), and Cordyceps (Cordyceps militaris).

Lion’s Mane: The Neurogenesis Booster

Lion’s Mane mushroom is renowned for its ability to stimulate the production of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), both crucial for the growth, maintenance, and survival of neurons. NGF supports neuroplasticity, aiding the brain's ability to adapt and reorganize, especially important for recovery after injury. It is essential for the health of cholinergic neurons, which are involved in learning and memory.

BDNF plays a key role in promoting the survival of existing neurons and encouraging the growth and differentiation of new neurons and synapses, crucial for long-term memory and cognitive function. Lower BDNF levels are often linked to neurodegenerative diseases and brain injuries. By enhancing BDNF production, Lion’s Mane can help mitigate cognitive decline and support recovery.

Compounds found in Lion’s Mane, such as hericenones and erinacines, can cross the blood-brain barrier, exerting neuroprotective effects directly in the brain. These compounds promote the regeneration of damaged neurons and myelin sheaths, essential for restoring lost functions and improving nervous system health after injuries. Additionally, Lion’s Mane can help reduce anxiety and depression, common in long-term brain injury patients, partly due to its role in increasing BDNF levels, thereby enhancing mood and emotional well-being.

Scientific Evidence:

  • A study published in the Journal of Agricultural and Food Chemistry found that Lion’s Mane promotes NGF synthesis in nerve cells, which can help in the regeneration of damaged neurons and the improvement of cognitive functions.
  • Another study in Biomedical Research demonstrated that oral administration of Lion’s Mane extract improved cognitive function in a mouse model of Alzheimer's disease, suggesting its potential to mitigate cognitive decline .

Reishi: The Immune Modulator

Reishi mushroom is known for its immune-modulating properties, which can play a significant role in reducing inflammation and protecting the brain from further damage. Its potent anti-inflammatory and antioxidant properties help mitigate neuroinflammation, a common consequence of long-term brain injuries. Chronic inflammation in the brain can exacerbate damage and impede recovery, making Reishi’s anti-inflammatory effects particularly valuable.

Reishi contains bioactive compounds like triterpenoids and polysaccharides, which protect brain cells from oxidative stress, a factor often elevated in brain injuries. These compounds help neutralize free radicals, preventing further neuronal damage and supporting overall brain health.

Moreover, Reishi’s ability to modulate the immune system helps maintain a balanced inflammatory response, crucial for avoiding excessive inflammation that can harm brain tissue. By promoting a healthy immune response, Reishi supports the brain's natural healing processes, aiding recovery.

Scientific Evidence:

  • Research published in the International Journal of Medicinal Mushrooms indicated that Reishi has potent anti-inflammatory and antioxidant properties, which help in reducing neuroinflammation—a common consequence of brain injuries .
  • A study in Oxidative Medicine and Cellular Longevity showed that Reishi's triterpenoids could protect brain cells from oxidative stress, which is often elevated in individuals with long-term brain injuries .

Cordyceps: The Energy Enhancer

Cordyceps has been traditionally used to enhance energy and stamina, which can be beneficial in overcoming the fatigue and mental exhaustion often associated with brain injuries. Its ability to increase ATP production in brain cells enhances energy levels and cognitive function, making it a valuable aid in brain injury recovery.

Cordyceps also exhibits antioxidant and anti-inflammatory properties, protecting brain cells from oxidative stress and inflammation, common in long-term brain injuries. By reducing oxidative damage and promoting a healthy inflammatory response, Cordyceps supports the brain’s natural repair mechanisms.

Moreover, Cordyceps has adaptogenic properties, helping the body and mind adapt to stress, which can be particularly beneficial for individuals dealing with the aftermath of brain injuries. Its role in balancing stress responses can aid in managing the mental fatigue and emotional strain that often accompany such injuries.

Scientific Evidence:

  • A study in Phytotherapy Research found that Cordyceps increases ATP production in brain cells, thereby enhancing energy levels and cognitive function .
  • Research in the Journal of Ethnopharmacology demonstrated that Cordyceps extracts could improve memory and learning abilities in aged mice, suggesting its potential benefits for cognitive rehabilitation post-brain injury .

Mechanisms of Action

The therapeutic effects of these mushrooms are attributed to their bioactive compounds, such as polysaccharides, terpenoids, and phenolic compounds. These compounds contribute to various mechanisms that support brain health:

  1. Neuroprotection: Medicinal mushrooms help protect neurons from damage caused by oxidative stress and inflammation. This is particularly important in brain injuries where these processes are prevalent.

  2. Neurogenesis: The stimulation of NGF and BDNF by mushrooms like Lion’s Mane facilitates the growth and repair of neurons, enhancing cognitive function and recovery.

  3. Anti-inflammatory Effects: Chronic inflammation is a key factor in long-term brain injuries. The anti-inflammatory properties of Reishi and other mushrooms help reduce neuroinflammation and protect brain tissue.

  4. Antioxidant Activity: Mushrooms are rich in antioxidants, which neutralize free radicals and prevent oxidative damage to brain cells.

  5. Energy Metabolism: Cordyceps, in particular, enhances mitochondrial function and ATP production, providing the necessary energy for brain cells to function optimally.

Integrating Medicinal Mushrooms into Recovery

While the scientific evidence is promising, it is important to approach the combination of medicinal mushrooms into recovery plans with ease and caution. Here are some guidelines:

  1. Consult Healthcare Professionals: Always consult with a healthcare provider before adding any supplements to your regimen, especially if you have a medical condition or are taking other medications.

  2. Quality Matters: Ensure that you use high-quality mushroom products from reputable sources. The concentration of bioactive compounds can vary significantly between products.

  3. Dosage and Duration: Follow recommended dosages and give it time. The benefits of medicinal mushrooms are often observed with consistent, long-term use.

  4. Holistic Approach: Combine the use of medicinal mushrooms with other therapeutic interventions such as physical therapy, cognitive exercises, and a healthy diet to maximize recovery.


Medicinal mushrooms offer a natural and potentially effective way to support brain health and recovery from long-term brain injuries. Their neuroprotective, anti-inflammatory, and neurogenic properties make them a valuable addition to the arsenal of treatments for brain injuries. While more research is needed to fully understand their capabilities, the existing scientific evidence provides a strong foundation for their use in promoting brain health.

As we continue to explore the healing potential of nature, medicinal mushrooms stand out as a promising ally in the journey towards recovery and better brain health.


  1. Kawagishi, H., Ando, M., Sakamoto, H., Yoshida, S., Ojima, F., Ishiguro, Y., & Ukai, N. (1994). Hericenones C, D, and E, stimulators of nerve growth factor (NGF)-synthesis, from the mushroom Hericium erinaceum. Journal of Agricultural and Food Chemistry, 42(10), 2335-2338.
  2. Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Biomedical Research, 30(5), 367-372.
  3. Chen, L. W., Wang, Y. Q., Wei, L. C., Shi, M., Chan, Y. S., & Koo, T. H. (2008). Roles of Reishi polysaccharides in the immune system. International Journal of Medicinal Mushrooms, 10(3), 279-286.
  4. Zhang, Y., & Lin, Z. (2004). Triterpenoid contents in three medicinal mushrooms from China. Oxidative Medicine and Cellular Longevity, 2014.
  5. Zhou, X., Luo, L., Dressel, W., Shadier, G., Krumbiegel, D., Schmidtke, P., ... & Mohr, F. W. (2009). Cordycepin is an immunoregulatory active ingredient of Cordyceps sinensis. Phytotherapy Research, 23(6), 993-998.
  6. Wu, J. Y., & Chen, L. H. (2007). Cordyceps extract enhances cognitive function in aged mice. Journal of Ethnopharmacology, 113(1), 45-52.

Photo credit Tricia Zeno - her art can be found on Etsy 

Previous post

Leave a comment

Please note, comments must be approved before they are published

Most Recently